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and bioconjugation
making it useful for both short- and long-term imaging applications
The TMP-tag is based on the tight binding between trimethoprim (TMP)
Nishiguchi
a Azide-Lys(m-PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility
Propargyl-Gly(m-PEG4)-Val-Ala-PAB(m-PEG8)-Exatecan aldehyde and bioconjugationSOLU KNEX cleavable linker features a Val Ala dipeptide. In this product, a Propargyl Gly(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. The propargyl functional group is widely employed in click chemistry to undergo selective cycloaddition with azides. Additionally, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further increase aqueous solubility. The
